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Drug: Estradiol

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Total 8747 results found since Jan 2013.

Serum estradiol level at intensive care unit admission and mortality in critically ill patients
Conclusions: The serum estradiol level is elevated in critically ill patients, regardless of gender, especially in those who die. It has good discriminative capacity to predict mortality, and it is an independent risk factor for death in this group of patients.
Source: Indian Journal of Critical Care Medicine - February 19, 2018 Category: Intensive Care Authors: Luis Alejandro Sanchez.Hurtado Rolando Lugo-Cob Brigette C Tejeda-Huezo Alejandro Esquivel-Ch & #225;vez Abraham A Cano-Oviedo Sergio Zamora-Varela Saira S Gomez-Flores Perla Arvizu-Tachiquin Jos & #233; A Baltazar-Torres Source Type: research

Higher Estradiol and Lower Dehydroepiandrosterone-Sulfate Levels Are Associated With Pulmonary Arterial Hypertension in Men.
CONCLUSIONS: Higher levels of E2 and lower levels of DHEA-S were associated with PAH in men. Sex-based differences in sex hormone processing and signaling may contribute to unique phenotypes in pulmonary vascular disease. PMID: 26651504 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - December 10, 2015 Category: Respiratory Medicine Authors: Ventetuolo CE, Baird GL, Barr RG, Bluemke DA, Fritz JS, Hill NS, Klinger JR, Lima JA, Ouyang P, Palevsky HI, Palmisciano AJ, Krishnan I, Pinder D, Preston IR, Roberts KE, Kawut SM Tags: Am J Respir Crit Care Med Source Type: research

Anastrozole in Pulmonary Arterial Hypertension (AIPH): A Randomized, Double-Blind Placebo-Controlled Trial.
CONCLUSIONS: Anastrozole significantly reduced E2 levels in patients with PAH, but had no effect on TAPSE. Anastrozole was safe, well-tolerated, and improved 6MWD in this small "proof-of-principle" study. Larger and longer Phase II clinical trials of anastrozole may be warranted in patients with PAH. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01545336. PMID: 27602993 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 6, 2016 Category: Respiratory Medicine Authors: Kawut SM, Archer-Chicko CL, DiMichele A, Fritz JS, Klinger JR, Ky B, Palevsky HI, Palmisciano AJ, Patel M, Pinder D, Propert KJ, Smith KA, Stanczyk F, Tracy R, Vaidya A, Whittenhall ME, Ventetuolo CE Tags: Am J Respir Crit Care Med Source Type: research

Sex Steroid Hormones and Asthma in a Nationwide Study of U.S. Adults.
CONCLUSIONS: Our findings suggest that sex hormones play a role in known sex differences in asthma in adults. Moreover, our results suggest that obesity modifies the effects of sex hormones on asthma in adults. PMID: 31525075 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - September 15, 2019 Category: Respiratory Medicine Authors: Han YY, Forno E, Celedón JC Tags: Am J Respir Crit Care Med Source Type: research

Pediatricians Who Serve Trans Youth Face Increasing Harassment. Lifesaving Care Could Be on the Line
Dr. Gina Sequeira first saw the protesters on a bright clear morning last September. A co-director of Seattle Children’s Gender Clinic who provides gender-affirming care to young people, Sequeira had confronted ignorance about her medical specialty in the past. But nothing had prepared her to see people outside her office, waving signs and handing out flyers warning of the “dangers” of the work she does. “That was really, really hard for us as a clinic,” she says. “And I think it was really hard for the hospital’s patients and families who witnessed it.” Just a month later, p...
Source: TIME: Health - February 16, 2022 Category: Consumer Health News Authors: Madeleine Carlisle Tags: Uncategorized feature Health Care LGBTQ nationpod News Source Type: news

Female Sex Hormone May Save Injured Soldiers On The Battlefield
This story was originally published by The UAB Mix. Breakthrough research suggests a female sex hormone may be the key to saving lives on the battlefield, where between 2001 and 2011 more than 80 percent of potentially preventable U.S. war injury deaths resulted from blood loss. The hormone shows the promise of prolonged survival despite massive loss of blood and could be carried in a small autoinjector for use. In a landmark step – after 19 years of research by Irshad Chaudry, Ph.D. – UAB has received a $10 million U.S. Department of Defense contract funded by the Combat Casualty Care Research Program, U.S. Ar...
Source: Science - The Huffington Post - October 30, 2015 Category: Science Source Type: news

A synopsis on current practice in the diagnosis and management of patients with Turner syndrome in Turkey: A survey of 18 pediatric endocrinology centers*
Conclusions: Although we found some conformity between the current consensus and practice of the participating centers in Turkey regarding TS, further improvements are mandatory in the multi-disciplinary approach to address co-morbidities, which if unrecognized, may be associated with reduced quality of life, and even mortality. PMID: 29699389 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 29, 2018 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Primary Ovarian Insufficiency in the Prepubertal Adolescent: A Case Report
Although there are many etiologies for delayed puberty in adolescent-aged girls, the pediatric provider should consider primary ovarian insufficiency if estradiol remains undetectable despite elevated levels of gonadotropins. Adolescent girls with this diagnosis will need holistic care from their primary care provider, focusing on both their medical and psychosocial needs. The following case study describes a 14-year-old girl who was referred to pediatric endocrinology for delayed puberty, in the setting of increased gonadotropins and undetectable estradiol.
Source: Journal of Pediatric Health Care - April 23, 2020 Category: Pediatrics Authors: Meghan C. McGowan, Elizabeth A. Doyle, Susan D. Boulware Tags: Case Reports Source Type: research

Risk for midlife psychosis in women: critical gaps and opportunities in exploring perimenopause and ovarian hormones as mechanisms of risk
Psychol Med. 2022 May 18:1-9. doi: 10.1017/S0033291722001143. Online ahead of print.ABSTRACTWomen show a heightened risk for psychosis in midlife that is not observed in men. The menopausal transition (i.e. perimenopause) and accompanying changes in ovarian hormones are theorized to account for this midlife increase in risk. This narrative review aims to empirically examine these theories by reviewing studies of midlife and perimenopausal psychosis risk in women and potential ovarian hormone mechanisms of effects. Clinical and pre-clinical studies examining the effects of midlife age, menopausal stage, and ovarian hormones...
Source: Psychological Medicine - May 18, 2022 Category: Psychiatry Authors: Kristen M Culbert Katharine N Thakkar Kelly L Klump Source Type: research

17β-Estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats
Conclusion: Estrogen may have a role in preserving body mass after severe thermal injury. Further studies are required to determine if this spared body mass composition.
Source: Journal of Surgical Research - June 21, 2012 Category: Surgery Authors: Kareem R. AbdelFattah, Joshua W. Gatson, David L. Maass, Steven E. Wolf, Joseph P. Minei, Jane G. Wigginton Tags: Shock/Sepsis/Trauma/Critical Care Source Type: research

Commentary: 17-β-estradiol reappropriates mass lost to the hypermetabolic state in thermally injured rats
Severe burns are among the most common causes of death from unintentional injury , and they remain an important subject in trauma and critical care medicine. The profound hypermetabolic and hypercatabolic states that are characteristic of severe thermal injury lead to extensive protein wasting, manifested as skeletal muscle breakdown, lean body mass loss, and negative nitrogen balance with subsequent compromised functional and structural changes of essential body organs . These changes occur in response to the release of proinflammatory cytokines and counter regulatory hormones that dramatically impair the anabolic states.
Source: Journal of Surgical Research - August 31, 2012 Category: Surgery Authors: Saad Shebrain, Jason Ryan Tags: Commentary Source Type: research

Role of Akt/HO-1 pathway in estrogen-mediated attenuation of trauma-hemorrhage-induced lung injury
Conclusions: Our results collectively suggest that Akt-dependent HO-1 upregulation may play a critical role in E2-meditated lung protection after trauma-hemorrhage.
Source: Journal of Surgical Research - November 22, 2012 Category: Surgery Authors: Jun-Te Hsu, Huei-Chung Yeh, Tsung-Hsing Chen, Chia-Jung Kuo, Chun-Jun Lin, Kun-Chun Chiang, Ta-Sen Yeh, Tsann-Long Hwang, Irshad I. Chaudry Tags: Shock/Sepsis/Trauma/Critical Care Source Type: research

Complex Biological Pattern of Fertility Hormones in Children and Adolescents: A Study of Healthy Children from the CALIPER Cohort and Establishment of Pediatric Reference Intervals Pediatric Clinical Chemistry
CONCLUSIONS: This comprehensive database of pediatric reference intervals for fertility hormones will be of global benefit and should lead to improved diagnosis of pediatric endocrinopathies. The new database will need to be validated in local populations and for other immunoassay platforms as recommended by the Clinical Laboratory Standards Institute.
Source: Clinical Chemistry - July 26, 2013 Category: Chemistry Authors: Konforte, D., Shea, J. L., Kyriakopoulou, L., Colantonio, D., Cohen, A. H., Shaw, J., Bailey, D., Chan, M. K., Armbruster, D., Adeli, K. Tags: Pediatric Clinical Chemistry Source Type: research

Downregulation of G ‑protein‑coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis.
Downregulation of G‑protein‑coupled receptor 30 in the hippocampus attenuates the neuroprotection of estrogen in the critical period hypothesis. Mol Med Rep. 2018 Feb 16;: Authors: Wu Y, Feng D, Lin J, Qu Y, He S, Wang Y, Gao G, Zhao T Abstract The aim of the present study was to investigate the role of G‑protein‑coupled receptor 30 (GPR30) in long‑term 17β‑estradiol (E2) deprivation (LTED) in a rat model with global cerebral ischemia (GCI), and its therapeutic target for ischemic stroke in the clinical setting. Following bilateral ovariectomy, GCI was induced in rats 1 or 10 weeks postâ€...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research